Hydroxocobalamin at Seattle Naturopathic Center

Hydroxocobalamin B12 is a natural and uniquely powerful form of vitamin B12. Clinical studies practice have shown it can help to improve cognitive function, fight fatigue, promote heart health and more.

Vitamin B12 is an essential nutrient needed to make red blood cells that carry oxygen throughout the body, the myelin sheath that surrounds nerve cells, and various proteins. It also plays a role in fat and carbohydrate metabolism. Studies have found that hydroxocoblamin raises B12 levels higher and lasts longer than cyanocobalamin (1,2). Hydroxocobalamin has a hihg affinity for cyanide. It pulls the cyanide out of the mitochondria of the cell and combines with it to form cyanocobalamin, which is then excreted in the urine. In 2006, hydroxocobalamin was approved by the FDA as an antidote for cyanide poisoning. Since cyanide is present in cigarette smoke ( and essentially reduces the cells’ ability to use oxygen), hydroxocobalamin would be a good option for smoker seeking a B12 supplement.

1. Hall CA, et al. “The availability of therapeutic hydroxocobalamin to cells.” Blood. 1984 Feb;63(2):335-41.
2. Glass GBJ, et al. “Hydroxocobalamin V. Prolonged maintenance of high vitamin B12 blood levels following a short course of hydrooxocobalamin injections.” Blood. 1966. Vol 27, No. 2 pp 234-241.